Ver a vida a passar pelos olhos

Um estudo que reporta os resultados de apenas uma amostra biológica, neste caso, de um paciente que morreu enquanto estava a fazer uma ressonancia magnética, mostra que provavelmente no momento da morte a vida realmente nos passa à frente dos olhos. Segundo os ciêntistas, este fenómeno é um misto de sonhar acordado e relembrar memórias.

A notícia do “Público” por Carla B. Ribeiro, a 25 de Fevereiro de 2022, 16:37

T cell response in Sars-CoV-2 immunity – a review by Paul Moss


A wide range of studies have shown that the T cell response is a
critical component of immune protection against SARS-CoV-2.
This should come as no surprise. Cellular immunity is essential for
the protection of multicellular organisms, and coronaviruses have
co-existed with Homo sapiens over long periods of time. Evidence
now suggests that SARS-CoV-2-specific T cell responses are essential for viral clearance, may prevent infection without seroconversion, provide robust memory, and mediate recognition of viral
variants. They are also elicited after vaccination, where they may
underpin outstanding protection against severe infection and death.
Antibody responses are clearly also highly effective in clinical protection, and their analysis has been facilitated by relative ease of
detection and assessment. Cellular responses remain more difficult to study, but this challenge is now being addressed during the
COVID-19 pandemic.

A nice read, that can be found here:

Impact of BCI on brain’s homeostasis

Neuralink, Elon Musk’s backed Brain Computer Interface company, is looking for a clinical trial director. Indeed, they have dozens of open positions and a very attractive website. This company aims at building a BCI system that can be used to help patients communicating through text and daily life devices. Initially, Musk has proposed that with this device, one could top up one’s own brain capacity. However, this seems to be more suited as the topic of science fiction than of real-life. Hence, the goal has been tweaked down a notch.

As with any other medical component, medical devices must go through highly regulated control and scrutiny. Among others, it must be shown that the device does not disturb brain homeostasis. This is quite difficult to prove, as (per figure below) it is quite easy to disturb the brain. Imagining a surgery to implant a device like the “link”, neuronal death and blood-brain-barrier dysfunction (opening) starts within minutes of the 1st procedure. Moreover, all other cells are affected within hours, with the activation of astrocytes and microglia, and scarization being the most important aspects. Not surprisingly, the immune system gets activated very early on as well, with macrophages and neutrophils being on the first line of response. A consequence of normal process of macrophage is that these cells become tissue resident macrophages. In the brain, it means that they become “microglia-like”, which makes a chronological timeline of events difficult to understand. As an example, if a device that has been implanted for four months has triggered an immune response at three months, when you collect the samples at 3.5 or 4 months, most macrophages that were triggered with the first event will now have differentiated into microglia – a typical brain cell. Hence, based on this observation alone, one would not be able to detect a problem. 

Even if most of these processes tend to stabilize over-time, they stabilize away from their basal level. Hence, appropriate control groups and time points must be chosen, so to understand the impact of a new device in brain homeostasis.


DOI: 10.3389/fnins.2019.00689

DOI: 10.1021/acschemneuro.7b00403

DOI: 10.1021/cn500256e

Chart, line chart

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Ok, I just made up that word but if it ever catches up, it was said here first!
I have stumbled upon a brief first-hand account of the issues caused by space flights, and could not stop thinking whether healthcare and research should start looking careful into some of these topics, considering the commercial space flights and the possibility of inter-planetary migration.